Author's response to reviews Title:Type X collagen levels are elevated in serum from human Osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation Authors:
نویسندگان
چکیده
Yi He ([email protected]) Anne S Siebuhr ([email protected]) Niels U Brandt-Hansen ([email protected]) Jianxia Wang ([email protected]) Di Su ([email protected]) Qinlong Zheng ([email protected]) Ole Simonsen ([email protected]) Kristian K Petersen ([email protected]) Lars Arendt-Nielsen ([email protected]) Thomas Eskehave ([email protected]) Hans C Hoeck ([email protected]) Morten A Karsdal ([email protected]) Anne C Bay-Jensen ([email protected])
منابع مشابه
Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation
BACKGROUND Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. Hypertrophy-like changes have been observed as part of the progression of OA. The aim of the study was to develop and characterize a novel biomarker of chondrocytes hypertrophy and investigate how this marker was associated with cartilage degradation and inflammati...
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BACKGROUND There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some serum biomarkers to be associated with a better response to chondroitin sulfate in reducing cartilage volume loss. METHODS Eight biomarkers were ...
متن کاملElevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement.
BACKGROUND Femoroacetabular impingement (FAI) is one of the most common causes of early cartilage and labral damage in the nondysplastic hip. Biomarkers of cartilage degradation and inflammation are associated with osteoarthritis. It was not known whether patients with FAI have elevated levels of biomarkers of cartilage degradation and inflammation. HYPOTHESIS Compared with athletes without F...
متن کاملHydroxypyridinium collagen crosslinks in serum, urine, synovial fluid and synovial tissue in patients with rheumatoid arthritis compared with osteoarthritis.
OBJECTIVE To investigate the relationship between inflammation markers and content of pyridinium crosslinks in hydrolysates of synovial tissue and to specify the significance of urinary excreted pyridinoline, released primarily from collagen I and II of bone and cartilage, and deoxypyridinoline released especially from collagen I of bone and dentin, dependent on disease activity in rheumatoid a...
متن کاملLevels of C-reactive protein, creatine kinase-muscle and aldolase A are suitable biomarkers to detect the risk factors for osteoarthritic disorders: A novel diagnostic protocol
Background: C-reactive protein (CRP), creatine kinase-muscle (CK-MM) and aldolase A (AldoA) levels are predicted to be realistic biomarkers of osteoarthritic disorders (OADs). The objective of the study was to evaluate the levels of CRP, CK-MM, and AldoA and determine their correlations with risk factors such as inflammation, muscle degeneration, and skeletal muscle damage for OADs. Methods: B...
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تاریخ انتشار 2014